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The cause of fibromyalgia remains unknown, but its prevalence reaches 3 percent of the population and is seven times greater for women than for men. Traditional pharmaceutical treatments target fibromyalgia symptom relief, but patients’ response is typically mixed, and medical cannabis has become a common alternative.

Fibromyalgia is a rheumatic disorder similar to arthritis. It is characterized by chronic pain throughout the body, heightened and painful response to pressure, insomnia, morning stiffness, and debilitating fatigue. Many factors are involved, including nervous and endocrine system abnormalities, genetic factors, social and genetic factors, and social and environmental stressors. 

Fibromyalgia remains poorly understood. It may result from overall central sensitization to pain signaling, a defect in neurotransmitter release, or the obstruction of pathways the body uses to inhibit pain signaling. It may also be the body’s response to stress. Many researchers believe it results from an imbalance of the endocannabinoid system wherein too much anandamide circulates throughout the body, which is likely a critical underlying factor.

Molecules to target fibromyalgia

Both THC and CBD are recommended, and THC/CBD hybrids are probably best. Again, it’s hard to go wrong with myrcene, limonene, and pinene in regards to terpenes. Also indicated are beta myrcene, beta-Caryophyllene, pinene, borneol, 1,8- cineole, and delta-3-carene because they are anti-inflammatories and eucalyptol already mentioned, has antinociceptive properties.

Dosing for fibromyalgia  

Patients have reported great success with initial doses equivalent to 4 milligrams of THC, the threshold of psychoactivity. This dose can be raised to 10 milligrams as needed but should be mitigated with CBD to maintain endocannabinoid balance.

Methods of ingestion

Because oral ingestion of cannabis delivers long-lasting effects, it is popular with fibromyalgia patients. Avoid over-medicating since it has been shown to increase pain in a University of California study. 

Vaporization is probably the best approach for controlling fibromyalgia pain because the medicinal effects are felt immediately, and the patient can titrate their dose.